Agave Mexican
137 Second St., Lewes, 645-1232 This popular spot features authentic, regional flavors of Mexico, plus a dizzying array of tequila. Regulars love the homemade guacamole and chiles enogado. L, D $$
Arena’s Café American
17314 N. Village Main Blvd., N.53, Lewes, 644-0370, arenasdeliandbar.com Hearty sandwiches like the Hungry Surfer and California Club Dude. B, L, D $
Annabella’s Italian Restaurant Italian
1201 Savannah Road, Lewes, 645-1980, annabellasrestaurant.com Fresh-made and creative pasta creations. L, D $
Bethany Blues of Lewes American
18385 Coastal Hwy., Lewes, 644-2500, bethanyblues.com Southern barbecue, seafood, steaks and St. Louis-style ribs with award-winning sauce, plus homemade birch beer. L, D, SB $$
The Buttery American
102 Second St., Lewes, 645-7755, butteryrestaurant.com Inspired global cuisine executed with a commitment to supporting local farmers. The fireplace and garden room of the former Victorian home are part of the allure. So is the list of boutique wines. L, D, SB $$$
Café Azafran Mediterranean
109 W. Market St., Lewes, 644-4446; 18 Baltimore Ave., Rehoboth, 227-8100; cafeazafran.com Espresso and coffee in the morning, Mediterranean salads and sandwiches at lunch, then tapas on summer evenings. B, L $$
Fish On American
Villages of Five Points, Lewes, 645-9790, fishon.bz The delicious food of the Chesapeake, including blue crabs and oysters, are prepared expertly, along with perfectly marbled steaks and succulent lobster. D $$$
Go Brit! British
18388 Coastal Hwy., Lewes, 644-2250, gobrit.com A classic fish-and-chips house also serves shepherd’s pie, classic sides like mushy peas and delicious sticky toffee pudding. L, D $$
Grotto Grand Slam Italian
17467 Shady Road and Del. 1, Lewes, 645-4900, grottopizza.com Pizzas made with a unique blend of cheeses, pastas, subs and more. The Grand Slam sports bar carries all the big games on big TVs. L, D $$
Half Full American
113 Market St., Lewes, 645-8877, halffulllewes.com An intimate downtown spot dedicated to great wine and crispy handmade pizza. Check in frequently for featured wines to accompany the pizzas, made with whole milk mozzarella. D $$
Irish Eyes Pub & Restaurant Pub
213 Anglers Road, Lewes, 645-6888, irisheyespub.com The diverse menu ranges from ribeye tacos to bangers and mash, with a deck on the Lewes-Rehoboth Canal. L, D $$
Jerry’s Seafood American
108 Second St., Lewes, 645-6611, jerrys-seafood.com Crab cakes, including the signature Crab Bomb, are joined by fried oysters, crispy calamari, steak and chicken. L, D $$$
JD’s Filling Station American
329 Savannah Road, Lewes, 644-8400, jdsfillingstation.com This family friendly place serves everything from omelets to burgers to Mexican dishes, seafood and steaks. B, L, D $
Kindle Restaurant & Lounge American
111 Bank St., Lewes, 645-7887, kindlerestaurant.com Regional American gets a French slant—broiled day boat scallops Mitonnée—in this cozy spot. L, D $$$
Lazy Susan’s Seafood Deli Seafood
18289 Coastal Hwy., Lewes, 645-5115 fb A favorite for steamed crabs and other seaside fare for more than 25 years. D $$
Notting Hill Coffee Roastery
124 Second St., Lewes, 645-0733, nottinghillcoffee.com The best coffee in town—and the best sticky buns, plus croissants and other baked goods. B, L $$
Striper Bites American
107 Savannah Road, Lewes, 645-4657, striperbites.com The menu gets an overhaul three times yearly, but some things at the cottage-style restaurant are constant: the nautical decor, great seafood dishes and burgers. L, D $$$
Villa Sorrento Italian
1551 Savannah Road, Lewes, 644-7052 Authentic Italian cuisine in a cozy, casual, atmosphere includes New York-style gourmet pizza, veal, seafood, homemade bread, pasta and sauces, plus a full wine list and cocktails. $$
